Methods: This descriptive-analytical and cross-sectional study was conducted in 2020 on 340 nurses from 10 educational hospitals affiliated to Shiraz University of Medical Sciences. The data collection tool was a questionnaire. Data were analyzed using t-test, ANOVA and Pearson correlation coefficient were analyzed using SPSS23 software .Results: According to the results, human factors have been the most important factor in the occurrence of medication errors. The most important causes of medication errors with respect to human, managerial and environmental factors include fatigue due to overwork (3.13 ± 1.16), method of supervision (3.06 ± 0.98) ,and heavy workload (3.00 ± 1.19), respectively. There was a statistically significant relationship between human factors and age (p = 0.024), gender (p = 0.013), employment relationship (p = 0.016), and marital status (p = 0.027), and between management factors and employment relationship (p = 0.034) and the number of patients under observation (p = 0.011).
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